Generation of Brain Microvascular Endothelial-like Cells from Human iPS Cell-Derived Endothelial Progenitor Cells Using TGF-β Receptor Inhibitor, Laminin 511 Fragment, and Neuronal Cell Culture Supplements

Generation of Brain Microvascular Endothelial-like Cells from Human iPS Cell-Derived Endothelial Progenitor Cells Using TGF-β Receptor Inhibitor, Laminin 511 Fragment, and Neuronal Cell Culture Supplements

Brain microvascular endothelial cells (BMECs) constitute the blood–brain barrier (BBB), which prevents the transfer of substances into the brain. Recently, in vitro BBB models using human-induced pluripotent stem (iPS) cell-derived brain microvascular endothelial-like cells (iBMELCs) have been creat...

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Bibliographic Details
Main Authors: Hiromasa Aoki, Misaki Yamashita, Tadahiro Hashita, Takahiro Iwao, Mineyoshi Aoyama, Tamihide Matsunaga
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
human-induced pluripotent stem cell
endothelial progenitor cell
brain microvascular endothelial cell
laminin511
blood–brain barrier
transforming growth factor-β receptor inhibitor
Online Access:https://www.mdpi.com/1999-4923/14/12/2697

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https://www.mdpi.com/1999-4923/14/12/2697

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