A Comparative Study of the Effect of Different Stabilizers on the Critical Quality Attributes of Self-Assembling Nano Co-Crystals

A Comparative Study of the Effect of Different Stabilizers on the Critical Quality Attributes of Self-Assembling Nano Co-Crystals

Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used orally to manage HIV/AIDS infection. A pseudo one-solvent bottom-up approach was used to develop and produce nano co-crystals of 3TC and AZT. Equimolar amounts of 3TC dissolved in de-ionized water and AZT in methanol were rapidly inject...

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Bibliographic Details
Main Authors: Bwalya A. Witika, Vincent J. Smith, Roderick B. Walker
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceutics
Subjects:
nano co-crystals
crystal engineering
polydispersity index
zeta potential
particle size
zidovudine
lamivudine
hiv/aids
sonochemistry
Online Access:https://www.mdpi.com/1999-4923/12/2/182

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https://www.mdpi.com/1999-4923/12/2/182

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