Omecamtiv mecarbil augments cardiomyocyte contractile activity both at resting and systolic Ca2+ levels

Omecamtiv mecarbil augments cardiomyocyte contractile activity both at resting and systolic Ca2+ levels

Abstract Aims Heart failure with reduced ejection fraction (HFrEF) is a disease with high mortality and morbidity. Recent positive inotropic drug developments focused on cardiac myofilaments, that is, direct activators of the myosin molecule and Ca2+ sensitizers for patients with advanced HFrEF. Ome...

Full description

Bibliographic Details
Main Authors: Arnold Péter Ráduly, Attila Tóth, Fruzsina Sárkány, Balázs Horváth, Norbert Szentandrássy, Péter P. Nánási, Zoltán Csanádi, István Édes, Zoltán Papp, Attila Borbély
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:ESC Heart Failure
Subjects:
Omecamtiv mecarbil
Heart failure with reduced ejection fraction
Myosin activators
Positive inotropy, diastolic dysfunction
Online Access:https://doi.org/10.1002/ehf2.14300

Internet

https://doi.org/10.1002/ehf2.14300

Similar Items