Bcl-xL/Bak interaction and regulation by miRNA let-7b in the intrinsic apoptotic pathway of stored platelets

Bcl-2 family proteins play key roles in the intrinsic apoptosis pathway in platelets, with both pro- and antiapoptotic protein expressions regulating survival during ex vivo storage. We detected a significant decrease in antiapoptotic Bcl-xL and increase in proapoptotic Bak expression on the third d...

Full description

Bibliographic Details
Main Authors: Yuzhong Yan, Rufeng Xie, Qi Zhang, Xinfang Zhu, Jia Han, Rong Xia
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Platelets
Subjects:
Online Access:http://dx.doi.org/10.1080/09537104.2017.1371289