Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice

Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice

DYT1 early-onset generalized torsion dystonia is a hereditary movement disorder characterized by abnormal postures and repeated movements. It is caused mainly by a heterozygous trinucleotide deletion in DYT1/TOR1A, coding for torsinA. The mutation may lead to a partial loss of torsinA function. Func...

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Bibliographic Details
Main Authors: Fumiaki Yokoi, Janneth Oleas, Hong Xing, Yuning Liu, Kelly M. Dexter, Carly Misztal, Melinda Gerard, Iakov Efimenko, Patrick Lynch, Matthew Villanueva, Raul Alsina, Shiv Krishnaswamy, David E. Vaillancourt, Yuqing Li
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Neurobiology of Disease
Subjects:
Beam walking
Cholinergic interneuron
Dopamine
Drd2-Cre
Dystonia
DYT1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303134

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http://www.sciencedirect.com/science/article/pii/S0969996119303134

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