Peptidome analysis of cerebrospinal fluid by LC-MALDI MS.

We report on the analysis of endogenous peptides in cerebrospinal fluid (CSF) by mass spectrometry. A method was developed for preparation of peptide extracts from CSF. Analysis of the extracts by offline LC-MALDI MS resulted in the detection of 3,000-4,000 peptide-like features. Out of these, 730 p...

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Bibliographic Details
Main Authors: Mikko Hölttä, Henrik Zetterberg, Ekaterina Mirgorodskaya, Niklas Mattsson, Kaj Blennow, Johan Gobom
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22880031/?tool=EBI