MHC class II complexes sample intermediate states along the peptide exchange pathway
MHCII proteins bind and present both foreign and self-antigens to potentially activate CD4+ T cells via cognate T cell receptors (TCRs) during the adaptive immune response. Here, the authors combine NMR-detected H/D exchange with Markov modelling analysis to shed light on the dynamics of MHCII pepti...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2016-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms13224 |