MHC class II complexes sample intermediate states along the peptide exchange pathway

MHC class II complexes sample intermediate states along the peptide exchange pathway

MHCII proteins bind and present both foreign and self-antigens to potentially activate CD4+ T cells via cognate T cell receptors (TCRs) during the adaptive immune response. Here, the authors combine NMR-detected H/D exchange with Markov modelling analysis to shed light on the dynamics of MHCII pepti...

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Bibliographic Details
Main Authors: Marek Wieczorek, Jana Sticht, Sebastian Stolzenberg, Sebastian Günther, Christoph Wehmeyer, Zeina El Habre, Miguel Álvaro-Benito, Frank Noé, Christian Freund
Format: Article
Language:English
Published: Nature Portfolio 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13224

Internet

https://doi.org/10.1038/ncomms13224

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