MHC class II complexes sample intermediate states along the peptide exchange pathway

MHCII proteins bind and present both foreign and self-antigens to potentially activate CD4+ T cells via cognate T cell receptors (TCRs) during the adaptive immune response. Here, the authors combine NMR-detected H/D exchange with Markov modelling analysis to shed light on the dynamics of MHCII pepti...

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Bibliographic Details
Main Authors: Marek Wieczorek, Jana Sticht, Sebastian Stolzenberg, Sebastian Günther, Christoph Wehmeyer, Zeina El Habre, Miguel Álvaro-Benito, Frank Noé, Christian Freund
Format: Article
Language:English
Published: Nature Portfolio 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13224