MHC class II complexes sample intermediate states along the peptide exchange pathway

MHC class II complexes sample intermediate states along the peptide exchange pathway

MHCII proteins bind and present both foreign and self-antigens to potentially activate CD4+ T cells via cognate T cell receptors (TCRs) during the adaptive immune response. Here, the authors combine NMR-detected H/D exchange with Markov modelling analysis to shed light on the dynamics of MHCII pepti...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Marek Wieczorek, Jana Sticht, Sebastian Stolzenberg, Sebastian Günther, Christoph Wehmeyer, Zeina El Habre, Miguel Álvaro-Benito, Frank Noé, Christian Freund
स्वरूप: लेख
भाषा:English
प्रकाशित: Nature Portfolio 2016-11-01
श्रृंखला:Nature Communications
ऑनलाइन पहुंच:https://doi.org/10.1038/ncomms13224

इंटरनेट

https://doi.org/10.1038/ncomms13224

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