Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9

Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9

Multifunctional proteins are evolutionary puzzles: how do proteins evolve to satisfy multiple functional constraints? S100A9 is one such multifunctional protein. It potently amplifies inflammation via Toll-like receptor four and is antimicrobial as part of a heterocomplex with S100A8. These two func...

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Bibliographic Details
Main Authors: Joseph L Harman, Andrea N Loes, Gus D Warren, Maureen C Heaphy, Kirsten J Lampi, Michael J Harms
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
protein evolution
pleiotropy
ancestral sequence reconstruction
inflammation
antimicrobial activity
mammals
Online Access:https://elifesciences.org/articles/54100

Internet

https://elifesciences.org/articles/54100

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