JBP485, A Dual Inhibitor of Organic Anion Transporters (OATs) and Renal Dehydropeptidase-I (DHP-I), Protects Against Imipenem-Induced Nephrotoxicity

JBP485, A Dual Inhibitor of Organic Anion Transporters (OATs) and Renal Dehydropeptidase-I (DHP-I), Protects Against Imipenem-Induced Nephrotoxicity

Imipenem (IMP) possesses a broad spectrum of antibacterial activity; however, nephrotoxicity limits its clinical application in patients with renal insufficiency. In our previous studies, a dipeptide, JBP485, a dipeptide with the chemical structure cyclo-trans-4-L-hydroxyprolyl-L-serine, was found t...

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Bibliographic Details
Main Authors: Chong Wang, Changyuan Wang, Jingjing Wu, Qiang Meng, Huan Jin, Huijun Sun, Taiichi Kaku, Jing Chen, Xiaokui Huo, Kexin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
Imipenem
JBP485
OATs
DHP-I
DDI
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.938813/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.938813/full

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