Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying

Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying

The present study explored vacuum drum drying (VDD) as an alternative technology for amorphous solid dispersions (ASDs) manufacture compared to hot-melt extrusion (HME) and spray drying (SD) focusing on downstream processability (powder properties, compression behavior and tablet performance). Riton...

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Bibliographic Details
Main Authors: Barbara V. Schönfeld, Ulrich Westedt, Karl G. Wagner
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Ritonavir
Hot-melt extrusion
Spray drying
Vacuum drum drying
Amorphous solid dispersion
Compression analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156721000311

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http://www.sciencedirect.com/science/article/pii/S2590156721000311

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