Single‐cell RNA sequencing reveals a mechanism underlying the susceptibility of the left atrial appendage to intracardiac thrombogenesis during atrial fibrillation

Single‐cell RNA sequencing reveals a mechanism underlying the susceptibility of the left atrial appendage to intracardiac thrombogenesis during atrial fibrillation

Abstract Background Atrial fibrillation (AF) is associated with an increased risk of thrombosis of the left atrial appendage (LAA). However, the molecular mechanisms underlying this site‐specificity remain poorly understood. Here, we present a comparative single‐cell transcriptional profile of paire...

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Bibliographic Details
Main Authors: Jie Yang, Hu Tan, Mengjia Sun, Renzheng Chen, Zhao Jian, Yuanbin Song, Jihang Zhang, Shizhu Bian, Bo Zhang, Yi Zhang, Xubin Gao, Zhen Chen, Boji Wu, Xiaowei Ye, Hailin Lv, Zhen Liu, Lan Huang
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Clinical and Translational Medicine
Subjects:
ADAMTS1
atrial fibrillation
endocardial endothelial cells
single‐cell RNA‐sequencing
TFPI family
thrombogenesis
Online Access:https://doi.org/10.1002/ctm2.1297

Internet

https://doi.org/10.1002/ctm2.1297

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