Solid Dispersions of Gefitinib with D-<i>α</i>-Tocopherol Polyethylene Glycol-1000 Succinate and 2-Hydroxypropyl <i>β</i>-Cyclodextrin Complex Improved Their Solubility, Dissolution and Apoptosis against A549 Cells

Solid Dispersions of Gefitinib with D-<i>α</i>-Tocopherol Polyethylene Glycol-1000 Succinate and 2-Hydroxypropyl <i>β</i>-Cyclodextrin Complex Improved Their Solubility, Dissolution and Apoptosis against A549 Cells

This study focuses on the development and characterization of solid dispersions (SDs) of Gefitinib (GEF) to improve its aqueous solubility and therapeutic activity against lung cancer. SDs were prepared by the co-precipitation method with tocopheryl-polyethylene-glycol succinate-1000 (TPGS) (F1), so...

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Bibliographic Details
Main Authors: Mohd Abul Kalam, Adel Ali Alhowyan, Sulaiman S. Alhudaithi, Mohd Shahnawaz Khan, Abdullah K. Alshememry, Musaed Alkholief
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Applied Sciences
Subjects:
Gefitinib
TPGS
solid dispersions
HP <i>β</i>-CD
lung cancer
A549 cells
Online Access:https://www.mdpi.com/2076-3417/13/19/10859

Internet

https://www.mdpi.com/2076-3417/13/19/10859

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