Characterizing DNA methylation signatures of retinoblastoma using aqueous humor liquid biopsy

Retinoblastoma response to treatment is difficult to predict. Here, the authors show that DNA methylation of cfDNA from aqueous humour is altered in retinoblastoma patients and can be used to identify the molecular subtypes and potentially predict treatment response.

Bibliographic Details
Main Authors: Hong-Tao Li, Liya Xu, Daniel J. Weisenberger, Meng Li, Wanding Zhou, Chen-Ching Peng, Kevin Stachelek, David Cobrinik, Gangning Liang, Jesse L. Berry
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33248-2