Dlk1 maintains adult mice long-term HSCs by activating Notch signaling to restrict mitochondrial metabolism

Dlk1 maintains adult mice long-term HSCs by activating Notch signaling to restrict mitochondrial metabolism

Abstract Background Adult hematopoietic stem cells (HSCs) homeostasis is critically important in maintaining lifelong hematopoiesis. However, how adult HSCs orchestrate its homeostasis remains not fully understood. Imprinted gene Dlk1 has been shown to play critical role in mouse embryonic hematopoi...

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Bibliographic Details
Main Authors: Deyu Huang, Yingli Han, Tian Tang, Lin Yang, Penglei Jiang, Wenchang Qian, Zhaoru Zhang, Xinyue Qian, Xin Zeng, Pengxu Qian
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Experimental Hematology & Oncology
Subjects:
Dlk1
HSCs
Mitochondrial metabolism
Notch
HSC transplantation
Online Access:https://doi.org/10.1186/s40164-022-00369-9

Internet

https://doi.org/10.1186/s40164-022-00369-9

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