Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer

Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer

Abstract During cancer development, tumor cells acquire changes that enable them to invade surrounding tissues and seed metastasis at distant sites. These changes contribute to the aggressiveness of metastatic cancer and interfere with success of therapy. Our comprehensive analysis of “matched” pair...

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Bibliographic Details
Main Authors: Maria Kondratyev, Aleksandra Pesic, Troy Ketela, Natalie Stickle, Christine Beswick, Zvi Shalev, Stefano Marastoni, Soroush Samadian, Anna Dvorkin-Gheva, Azin Sayad, Mikhail Bashkurov, Pedro Boasquevisque, Alessandro Datti, Trevor J. Pugh, Carl Virtanen, Jason Moffat, Reidar A. Grénman, Marianne Koritzinsky, Bradly G. Wouters
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04828-9

Internet

https://doi.org/10.1038/s42003-023-04828-9

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