Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells [version 2; peer review: 2 approved]

Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells [version 2; peer review: 2 approved]

Background: Resolving causal genes for type 2 diabetes at loci implicated by genome-wide association studies (GWAS) requires integrating functional genomic data from relevant cell types. Chromatin features in endocrine cells of the pancreatic islet are particularly informative and recent studies lev...

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Bibliographic Details
Main Authors: Jason M. Torres, Vibe Nylander, Han Sun, Martijn van de Bunt, Damien J. Downes, Mark I. McCarthy, Jim R. Hughes, Anna L. Gloyn
Format: Article
Language:English
Published: Wellcome 2023-08-01
Series:Wellcome Open Research
Subjects:
type 2 diabetes
Capture-C
EndoC-βH1 cells
human islets
genetic regulation
chromatin interactions
eng
Online Access:https://wellcomeopenresearch.org/articles/8-165/v2

Internet

https://wellcomeopenresearch.org/articles/8-165/v2

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