Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions

Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions

Objectives: Improvements in human stem cell-derived cardiomyocyte (hSC-CM) technology have promoted their use for drug testing and disease investigations. Several in silico hSC-CM models have been proposed to augment interpretation of experimental findings through simulations. This work aims to asse...

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Bibliografski detalji
Glavni autori: Michelangelo Paci, Jussi T. Koivumäki, Hua Rong Lu, David J. Gallacher, Elisa Passini, Blanca Rodriguez
Format: Članak
Jezik:English
Izdano: Frontiers Media S.A. 2021-03-01
Serija:Frontiers in Pharmacology
Teme:
human stem cell-derived cardiomyocyte
action potential
calcium transient
in silico modeling
drug test
sensitivity analysis
Online pristup:https://www.frontiersin.org/articles/10.3389/fphar.2021.604713/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.604713/full

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