Anxiolytic and antidepressant like effects of Zamzam water in STZ-induced diabetic rats, targeting oxidative stress, neuroinflammation, BDNF/ERK/CREP pathway with modulation of hypothalamo-pituitary–adrenal axis

Anxiolytic and antidepressant like effects of Zamzam water in STZ-induced diabetic rats, targeting oxidative stress, neuroinflammation, BDNF/ERK/CREP pathway with modulation of hypothalamo-pituitary–adrenal axis

IntroductionRecent studies have reported a strong relationship between diabetes and anxiety- and depression-like behaviors; however, there is a lack of information on the underlying pathophysiology. Alkaline Zamzam water (ZW), which is rich in several trace elements, has neuroprotective properties....

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Bibliographic Details
Main Authors: Medhat Taha, Mohamed Ezzat Mahmoud, Abdullah G. Al-Kushi, Anas Sarhan, Omer Abdelbagi, Tourki A. S. Baokbah, Omar Babateen, Ibrahim El-Shenbaby, Naeem F. Qusty, Sara T. Elazab
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Neuroscience
Subjects:
anxiety
depression
Zamzam water
diabetes
oxidative stress
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1265134/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1265134/full

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