The prostaglandin F synthase activity of the human aldose reductase AKR1B1 brings new lenses to look at pathologic conditions.

The prostaglandin F synthase activity of the human aldose reductase AKR1B1 brings new lenses to look at pathologic conditions.

Prostaglandins are important regulators of female reproductive functions to which aldose reductases exhibiting hydroxysteroid dehydrogenase activity also contribute. Our work on the regulation of reproductive function by prostaglandins (PGs), lead us to the discovery that AKR1B5 and later AKR1B1 wer...

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Bibliographic Details
Main Authors: Eva eBresson, Nicolas eLacroix-Péppin, Sofia eBoucher-Kovalik, Pierre eChapdelaine, Michel A Fortier
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Pharmacology
Subjects:
Endothelial Cells
Glucose
Ischemia
Prostaglandin biosynthesis
Aldose reductase inhibitors
Human endometrium
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00098/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00098/full

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