Sertaconazole-Nitrate-Loaded Leciplex for Treating Keratomycosis: Optimization Using D-Optimal Design and In Vitro, Ex Vivo, and In Vivo Studies

Sertaconazole-Nitrate-Loaded Leciplex for Treating Keratomycosis: Optimization Using D-Optimal Design and In Vitro, Ex Vivo, and In Vivo Studies

This study aims to develop efficient topical therapy for keratomycosis using sertaconazolenitrate (STZN)-loaded leciplex (LP). The D-optimal design was used to optimize STZN-loaded LP by utilizing soy phosphatidylcholine (SPC) molar ratio (X<sub>1</sub>), cationic surfactant molar ratio...

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Bibliographic Details
Main Authors: Menna M. Abdellatif, Mina Josef, Mohamed A. El-Nabarawi, Mahmoud Teaima
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
keratomycosis
sertaconazole nitrate
D-optimal design
ocular drug delivery
Online Access:https://www.mdpi.com/1999-4923/14/10/2215

Internet

https://www.mdpi.com/1999-4923/14/10/2215

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