Cryptolepine suppresses breast adenocarcinoma via inhibition of HIF-1 mediated glycolysis

Cryptolepine suppresses breast adenocarcinoma via inhibition of HIF-1 mediated glycolysis

As a characteristic transcription factor in solid tumors, hypoxia inducible factor-1 (HIF-1) acts as a master regulator in breast cancer progression. Cryptolepine, as a natural alkaloid, noticeably inhibited HIF-1 transcriptional activity and decreased the protein expression of hypoxia-induced HIF-1...

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Bibliographic Details
Main Authors: Zhiyuan Zheng, Ting Xu, Zhiyan Liu, Wenyue Tian, Zhi-Hong Jiang, Guo-Yuan Zhu, Ting Li, Jin Gao, Li-Ping Bai
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cryptolepine (CLP)
Hypoxia inducible factor-1 (HIF-1)
Glycolysis
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222007089

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http://www.sciencedirect.com/science/article/pii/S0753332222007089

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