Resveratrol and FGF1 Synergistically Ameliorates Doxorubicin-Induced Cardiotoxicity via Activation of SIRT1-NRF2 Pathway

Resveratrol and FGF1 Synergistically Ameliorates Doxorubicin-Induced Cardiotoxicity via Activation of SIRT1-NRF2 Pathway

Doxorubicin (DOX) has received attention due to dose-dependent cardiotoxicity through abnormal redox cycling. Native fibroblast growth factor 1 (FGF1) is known for its anti-oxidative benefits in cardiovascular diseases, but possesses a potential tumorigenic risk. Coincidentally, the anti-proliferati...

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Bibliographic Details
Main Authors: Guangping Lu, Qingbo Liu, Ting Gao, Jiahao Li, Jingjing Zhang, Ou Chen, Cong Cao, Min Mao, Mengjie Xiao, Xiaohui Zhang, Jie Wang, Yuanfang Guo, Yufeng Tang, Junlian Gu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Nutrients
Subjects:
doxorubicin
cardiotoxicity
SIRT1
NRF2
oxidative stress
Online Access:https://www.mdpi.com/2072-6643/14/19/4017

Internet

https://www.mdpi.com/2072-6643/14/19/4017

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