Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy

Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy

Patients with refractory or recurrent B-lineage hematologic malignancies have less than 50% of chance of cure despite intensive therapy and innovative approaches are needed. We hypothesize that gene modification of haematopoietic stem cells (HSC) with an anti-CD19 chimeric antigen receptor (CAR) wil...

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Bibliographic Details
Main Authors: Sarah M. Larson, Laurel C. Truscott, Tzu-Ting Chiou, Amie Patel, Roy Kao, Andy Tu, Tulika Tyagi, Xiang Lu, David Elashoff, Satiro N. De Oliveira
Format: Article
Language:English
Published: Taylor & Francis Group 2017-05-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
car
cancer immunotherapy
gene therapy
hsc
suicide gene
Online Access:http://dx.doi.org/10.1080/21645515.2016.1268745

Internet

http://dx.doi.org/10.1080/21645515.2016.1268745

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