A Synthetic Tetramer of Galectin-1 and Galectin-3 Amplifies Pro-apoptotic Signaling by Integrating the Activity of Both Galectins

A Synthetic Tetramer of Galectin-1 and Galectin-3 Amplifies Pro-apoptotic Signaling by Integrating the Activity of Both Galectins

Galectin-1 (G1) and galectin-3 (G3) are carbohydrate-binding proteins that can signal apoptosis in T cells. We recently reported that a synthetic tetramer with two G1 and two G3 domains (“G1/G3 Zipper”) induces Jurkat T cell death more potently than G1. The pro-apoptotic signaling pathway of G1/G3 Z...

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Bibliographic Details
Main Authors: Shaheen A. Farhadi, Margaret M. Fettis, Renjie Liu, Gregory A. Hudalla
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Chemistry
Subjects:
galectin-1
galectin-3
glycobiology
protein engineering
protein-carbohydrate binding
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00898/full

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https://www.frontiersin.org/article/10.3389/fchem.2019.00898/full

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