Immunomodulation of Natural Killer Cell Function by Ribavirin Involves TYK-2 Activation and Subsequent Increased IFN-γ Secretion in the Context of In Vitro Hepatitis E Virus Infection

Immunomodulation of Natural Killer Cell Function by Ribavirin Involves TYK-2 Activation and Subsequent Increased IFN-γ Secretion in the Context of In Vitro Hepatitis E Virus Infection

Hepatitis E virus (HEV) is a major cause of acute hepatitis globally. Chronic and fulminant courses are observed especially in immunocompromised transplant recipients since administration of ribavirin (RBV) does not always lead to a sustained virologic response. By in vitro stimulation of NK cells t...

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Bibliographic Details
Main Authors: Paul Kupke, Akinbami Adenugba, Mathias Schemmerer, Florian Bitterer, Hans J. Schlitt, Edward K. Geissler, Jürgen J. Wenzel, Jens M. Werner
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
ribavirin
hepatitis E virus
transplantation
immunosuppression
NK cells
Online Access:https://www.mdpi.com/2073-4409/12/3/453

Internet

https://www.mdpi.com/2073-4409/12/3/453

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