Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines

Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines

ABSTRACT Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with multifunctional roles in virus replication and a potent antagonist of host immune response. Deletion of NS1 (DelNS1) would create a safer and more extensively immunogenic live attenuated influenza virus (LAIV)...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: Pui Wang, Min Zheng, Siu-Ying Lau, Pin Chen, Bobo Wing-Yee Mok, Siwen Liu, Honglian Liu, Xiaofeng Huang, Conor J. Cremin, Wenjun Song, Yixin Chen, Yik-Chun Wong, Haode Huang, Kelvin Kai-Wong To, Zhiwei Chen, Ningshao Xia, Kwok-Yung Yuen, Honglin Chen
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: American Society for Microbiology 2019-10-01
Loạt:mBio
Những chủ đề:
live attenuated vaccine
NS1
influenza vaccines
Truy cập trực tuyến:https://journals.asm.org/doi/10.1128/mBio.02180-19

Internet

https://journals.asm.org/doi/10.1128/mBio.02180-19

Những quyển sách tương tự