A novel CPT1A covalent inhibitor modulates fatty acid oxidation and CPT1A-VDAC1 axis with therapeutic potential for colorectal cancer

A novel CPT1A covalent inhibitor modulates fatty acid oxidation and CPT1A-VDAC1 axis with therapeutic potential for colorectal cancer

Colorectal cancer (CRC) is a common and deadly disease of the digestive system, but its targeted therapy is hampered by the lack of reliable and specific biomarkers. Hence, discovering new therapeutic targets and agents for CRC is an urgent and challenging task. Here we report that carnitine palmito...

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Bibliographic Details
Main Authors: Anni Hu, Hang Wang, Qianqian Xu, Yuqi Pan, Zeyu Jiang, Sheng Li, Yi Qu, Yili Hu, Hao Wu, Xinzhi Wang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Redox Biology
Subjects:
Colorectal cancer
2,6-Dihydroxypeperomin B
CPT1A
Covalent inhibitor
VDAC1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723003609

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http://www.sciencedirect.com/science/article/pii/S2213231723003609

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