A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery

Steven Chen et al. develop an automated, time-lapsed, high-content screen to quantify the responses of Schistosoma mansoni larvae to chemical insult. They apply their method to evaluate 45 static and kinetic response endpoints for seven drugs and screen 1323 approved drugs. Their work identifies ant...

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Bibliographic Details
Main Authors: Steven Chen, Brian M. Suzuki, Jakob Dohrmann, Rahul Singh, Michelle R. Arkin, Conor R. Caffrey
Format: Article
Language:English
Published: Nature Portfolio 2020-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01402-5