Shift in G<sub>1</sub>-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation

Shift in G<sub>1</sub>-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation

The current view of the involvement of PI3-kinases in checkpoint responses after DNA damage is that ATM is the key regulator of G<sub>1</sub>-, S- or G<sub>2</sub>-phase checkpoints, that ATR is only partly involved in the regulation of S- and G<sub>2</sub>-phase...

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Bibliographic Details
Main Authors: Fanghua Li, Emil Mladenov, Rositsa Dueva, Martin Stuschke, Beate Timmermann, George Iliakis
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
cell cycle
ionizing radiation
DNA double-strand breaks
checkpoints
DNA end resection
ATM
Online Access:https://www.mdpi.com/2073-4409/11/1/63

Internet

https://www.mdpi.com/2073-4409/11/1/63

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