Enhancement of TEX264-Mediated ER-Phagy Contributes to the Therapeutic Effect of Glycycoumarin against APA Hepatotoxicity in Mice

Enhancement of TEX264-Mediated ER-Phagy Contributes to the Therapeutic Effect of Glycycoumarin against APA Hepatotoxicity in Mice

Acetaminophen (APA)-induced hepatotoxicity is coupled with the activation of autophagy. We sought to determine whether selective autophagy of the endoplasmic reticulum (ER), termed ER-phagy, is involved in APA hepatotoxicity and to explore its potential as a therapeutic target for APA-induced liver...

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Bibliographic Details
Main Authors: Mingzhu Yan, Zhi Wang, Tianji Xia, Suwei Jin, Yongguang Liu, Hongbo Hu, Qi Chang
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomedicines
Subjects:
acetaminophen
hepatotoxicity
ER-phagy
TEX264
ER stress
glycycoumarin
Online Access:https://www.mdpi.com/2227-9059/9/8/939

Internet

https://www.mdpi.com/2227-9059/9/8/939

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