Opipramol Inhibits Lipolysis in Human Adipocytes without Altering Glucose Uptake and Differently from Antipsychotic and Antidepressant Drugs with Adverse Effects on Body Weight Control

Opipramol Inhibits Lipolysis in Human Adipocytes without Altering Glucose Uptake and Differently from Antipsychotic and Antidepressant Drugs with Adverse Effects on Body Weight Control

Treatment with several antipsychotic drugs exhibits a tendency to induce weight gain and diabetic complications. The proposed mechanisms by which the atypical antipsychotic drug olanzapine increases body weight include central dysregulations leading to hyperphagia and direct peripheral impairment of...

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Bibliographic Details
Main Authors: Christian Carpéné, Francisco Les, Josep Mercader, Saioa Gomez-Zorita, Jean-Louis Grolleau, Nathalie Boulet, Jessica Fontaine, Mari Carmen Iglesias-Osma, Maria José Garcia-Barrado
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceuticals
Subjects:
adipose tissue
obesity
monoamine oxidase
semicarbazide-sensitive amine oxidase
glucose transport
lipotoxicity
insulin
antidepressant
antipsychotic
harmine
phenelzine
opipramol
Online Access:https://www.mdpi.com/1424-8247/13/3/41

Internet

https://www.mdpi.com/1424-8247/13/3/41

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