Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules

Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules

In recent years, immunotherapy has shown considerable promise in the management of several malignancies. However, the majority of preclinical studies have been conducted in rodents, the results of which often translate poorly to patients given the substantial differences between murine and human imm...

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Bibliographic Details
Main Authors: Nana H. Overgaard, Daniel R. Principe, Kyle M. Schachtschneider, Jeanne Toft Jakobsen, Laurie A. Rund, Paul J. Grippo, Lawrence B. Schook, Gregers Jungersen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
porcine cancer model
comparative oncology
translational immunology
antitumor immunity
T cells
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01301/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01301/full

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