Obesity Contributes to Transformation of Myometrial Stem-Cell Niche to Leiomyoma via Inducing Oxidative Stress, DNA Damage, Proliferation, and Extracellular Matrix Deposition

Obesity Contributes to Transformation of Myometrial Stem-Cell Niche to Leiomyoma via Inducing Oxidative Stress, DNA Damage, Proliferation, and Extracellular Matrix Deposition

Leiomyomas (fibroids) are monoclonal tumors in which myometrial stem cells (MSCs) turn tumorigenic after mutation, abnormal methylation, or aberrant signaling. Several factors contribute to metabolic dysfunction in obesity, including abnormal cellular proliferation, oxidative stress, and DNA damage....

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Bibliographic Details
Main Authors: Sadia Afrin, Gregory W. Kirschen, Mostafa A. Borahay
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Genes
Subjects:
adipocytes
adipokines
leptin
fibroid
collagen
Online Access:https://www.mdpi.com/2073-4425/14/8/1625

Internet

https://www.mdpi.com/2073-4425/14/8/1625

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