Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women.

Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women.

Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using DNA pooling. We found a female-specific association with rs7341475, a SNP in the fourth intron of th...

Full description

Bibliographic Details
Main Authors: Sagiv Shifman, Martina Johannesson, Michal Bronstein, Sam X Chen, David A Collier, Nicholas J Craddock, Kenneth S Kendler, Tao Li, Michael O'Donovan, F Anthony O'Neill, Michael J Owen, Dermot Walsh, Daniel R Weinberger, Cuie Sun, Jonathan Flint, Ariel Darvasi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2242812?pdf=render

Internet

http://europepmc.org/articles/PMC2242812?pdf=render

Similar Items