Exploring the Impact of Cleavage and Polyadenylation Factors on Pre-mRNA Splicing Across Eukaryotes

Exploring the Impact of Cleavage and Polyadenylation Factors on Pre-mRNA Splicing Across Eukaryotes

In human, mouse, and Drosophila, the spliceosomal complex U1 snRNP (U1) protects transcripts from premature cleavage and polyadenylation at proximal intronic polyadenylation signals (PAS). These U1-mediated effects preserve transcription integrity, and are known as telescripting. The watchtower role...

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Bibliographic Details
Main Authors: Gildas Lepennetier, Francesco Catania
Format: Article
Language:English
Published: Oxford University Press 2017-07-01
Series:G3: Genes, Genomes, Genetics
Subjects:
AAUAAA
splicing
polyadenylation
U1 snRNP
transcription
gene
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.041483

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.041483

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