Global Proteomics for Identifying the Alteration Pathway of Niemann–Pick Disease Type C Using Hepatic Cell Models

Global Proteomics for Identifying the Alteration Pathway of Niemann–Pick Disease Type C Using Hepatic Cell Models

Niemann–Pick disease type C (NPC) is an autosomal recessive disorder with progressive neurodegeneration. Although the causative genes were previously identified, NPC has unclear pathophysiological aspects, and patients with NPC present various symptoms and onset ages. However, various novel biomarke...

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Bibliographic Details
Main Authors: Keitaro Miyoshi, Eiji Hishinuma, Naomi Matsukawa, Yoshitaka Shirasago, Masahiro Watanabe, Toshihiro Sato, Yu Sato, Masaki Kumondai, Masafumi Kikuchi, Seizo Koshiba, Masayoshi Fukasawa, Masamitsu Maekawa, Nariyasu Mano
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
Niemann–Pick disease type C
global proteomics
liquid chromatography–electrospray ionization tandem mass spectrometry
model cell
knock out
enrichment pathway analysis
Online Access:https://www.mdpi.com/1422-0067/24/21/15642

Internet

https://www.mdpi.com/1422-0067/24/21/15642

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