A Lacticaseibacillus rhamnosus secretome induces immunoregulatory transcriptional, functional and immunometabolic signatures in human THP-1 monocytes

Abstract Macrophage responses to activation are fluid and dynamic in their ability to respond appropriately to challenges, a role integral to host defence. While bacteria can influence macrophage differentiation and polarization into pro-inflammatory and alternatively activated phenotypes through di...

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Bibliographic Details
Main Authors: Michael P. Jeffrey, Lin Saleem, Chad W. MacPherson, Thomas A. Tompkins, Sandra T. Clarke, Julia M. Green-Johnson
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-56420-8