Pharmacophore Mapping Combined with dbCICA Reveal New Structural Features for the Development of Novel Ligands Targeting α4β2 and α7 Nicotinic Acetylcholine Receptors

Pharmacophore Mapping Combined with dbCICA Reveal New Structural Features for the Development of Novel Ligands Targeting α4β2 and α7 Nicotinic Acetylcholine Receptors

The neuronal nicotinic acetylcholine receptors (nAChRs) belong to the ligand-gated ion channel (GLIC) group, presenting a crucial role in several biological processes and neuronal disorders. The α4β2 and α7 nAChRs are the most abundant in the central nervous system (CNS), being involved in challengi...

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Bibliographic Details
Main Authors: Victor S. Batista, Adriano Marques Gonçalves, Nailton M. Nascimento-Júnior
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
pharmacophore mapping
dbCICA
drug design
α4β2 nAChRs
α7 nAChRs
molecular docking
Online Access:https://www.mdpi.com/1420-3049/27/23/8236

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https://www.mdpi.com/1420-3049/27/23/8236

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