Neonatal Fc receptor-targeted lignin-encapsulated porous silicon nanoparticles for enhanced cellular interactions and insulin permeation across the intestinal epithelium

Neonatal Fc receptor-targeted lignin-encapsulated porous silicon nanoparticles for enhanced cellular interactions and insulin permeation across the intestinal epithelium

Oral insulin delivery could change the life of millions of diabetic patients as an effective, safe, easy-to-use, and affordable alternative to insulin injections, known by an inherently thwarted patient compliance. Here, we designed a multistage nanoparticle (NP) system capable of circumventing the...

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Bibliographic Details
Main Authors: João P. Martins, Patrícia Figueiredo, Shiqi Wang, Erika Espo, Elena Celi, Beatriz Martins, Marianna Kemell, Karina Moslova, Ermei Mäkilä, Jarno Salonen, Mauri A. Kostiainen, Christian Celia, Vincenzo Cerullo, Tapani Viitala, Bruno Sarmento, Jouni Hirvonen, Hélder A. Santos
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-03-01
Series:Bioactive Materials
Subjects:
Nanoparticles
Porous silicon
Lignin
FcRn
Insulin
Oral drug delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21003819

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http://www.sciencedirect.com/science/article/pii/S2452199X21003819

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