Hydrogen Bonds, Topologies, Energy Frameworks and Solubilities of Five Sorafenib Salts

Hydrogen Bonds, Topologies, Energy Frameworks and Solubilities of Five Sorafenib Salts

Sorafenib (Sor) is an oral multi-kinase inhibitor, but its water solubility is very low. To improve its solubility, sorafenib hydrochloride hydrate, sorafenib hydrobromide and sorafenib hydrobromide hydrate were prepared in the mixed solvent of the corresponding acid solution, and tetrahydrofuran (T...

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Bibliographic Details
Main Authors: Chiuyen Phan, Jie Shen, Kaxi Yu, Jiyong Liu, Guping Tang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
sorafenib
hydrogen bond
topology
energy framework
solubility
Online Access:https://www.mdpi.com/1422-0067/22/13/6682

Internet

https://www.mdpi.com/1422-0067/22/13/6682

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