Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei

ABSTRACT In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system. DNA double-strand breaks (DSB) trigger VSG switching, and repair via gene...

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Detaylı Bibliyografya
Asıl Yazarlar: Emilia Jane McLaughlin, Karinna Rubio-Pena, Annick Dujeancourt-Henry, Lucy Glover
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: American Society for Microbiology 2022-04-01
Seri Bilgileri:mBio
Konular:
Online Erişim:https://journals.asm.org/doi/10.1128/mbio.03847-21