Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei
ABSTRACT In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system. DNA double-strand breaks (DSB) trigger VSG switching, and repair via gene...
Asıl Yazarlar: | , , , |
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Materyal Türü: | Makale |
Dil: | English |
Baskı/Yayın Bilgisi: |
American Society for Microbiology
2022-04-01
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Seri Bilgileri: | mBio |
Konular: | |
Online Erişim: | https://journals.asm.org/doi/10.1128/mbio.03847-21 |