Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control

Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control

Abstract Background Despite the low level of viral replication in HIV controllers (HICs), studies have reported viral mutations related to escape from cytotoxic T-lymphocyte (CTL) response in HIV-1 plasma sequences. Thus, evaluating the dynamics of the emergence of CTL-escape mutants in HICs reservo...

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Main Authors: Diogo Gama Caetano, Fernanda Heloise Côrtes, Gonzalo Bello, Sylvia Lopes Maia Teixeira, Brenda Hoagland, Beatriz Grinsztejn, Valdilea Gonçalves Veloso, Monick Lindenmeyer Guimarães, Mariza Gonçalves Morgado
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Retrovirology
Subjects:
HIV-1
HIV controller
CTL epitope
Single-nucleotide polymorphism
Escape mutant
Next-generation sequencing
Online Access:http://link.springer.com/article/10.1186/s12977-018-0444-z

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http://link.springer.com/article/10.1186/s12977-018-0444-z

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