The impact of DNMT3A variant allele frequency and two different comutations on patients with de novo cytogenetically normal acute myeloid leukemia

The impact of DNMT3A variant allele frequency and two different comutations on patients with de novo cytogenetically normal acute myeloid leukemia

Abstract To refine the biological and prognostic significance of DNMT3A mutations in acute myeloid leukemia (AML), we assessed the impact of DNMT3A variant allele frequency (VAF) and its comutations in this study. Using targeted next‐generation sequencing, we analyzed 171 adult patients with de novo...

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Bibliographic Details
Main Authors: Xian Chen, Chuchu Tian, Zhuanghui Hao, Lingang Pan, Minglin Hong, Wei Wei, Daniel Muteb Muyey, Hongwei Wang, Xiuhua Chen
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Cancer Medicine
Subjects:
acute myeloid leukemia
DNMT3A mutations
variant allele frequency
Online Access:https://doi.org/10.1002/cam4.5764

Internet

https://doi.org/10.1002/cam4.5764

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