Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants
Summary: Induction of protective mucosal T cell memory remains a formidable challenge to vaccinologists. Using a combination adjuvant strategy that elicits potent CD8 and CD4 T cell responses, we define the tenets of vaccine-induced pulmonary T cell immunity. An acrylic-acid-based adjuvant (ADJ), in...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Cell Reports Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266637912030121X |
| _version_ | 1811294805281472512 |
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| author | Chandranaik B. Marinaik Brock Kingstad-Bakke Woojong Lee Masato Hatta Michelle Sonsalla Autumn Larsen Brandon Neldner David J. Gasper Ross M. Kedl Yoshihiro Kawaoka M. Suresh |
| author_facet | Chandranaik B. Marinaik Brock Kingstad-Bakke Woojong Lee Masato Hatta Michelle Sonsalla Autumn Larsen Brandon Neldner David J. Gasper Ross M. Kedl Yoshihiro Kawaoka M. Suresh |
| author_sort | Chandranaik B. Marinaik |
| collection | DOAJ |
| description | Summary: Induction of protective mucosal T cell memory remains a formidable challenge to vaccinologists. Using a combination adjuvant strategy that elicits potent CD8 and CD4 T cell responses, we define the tenets of vaccine-induced pulmonary T cell immunity. An acrylic-acid-based adjuvant (ADJ), in combination with Toll-like receptor (TLR) agonists glucopyranosyl lipid adjuvant (GLA) or CpG, promotes mucosal imprinting but engages distinct transcription programs to drive different degrees of terminal differentiation and disparate polarization of TH1/TC1/TH17/TC17 effector/memory T cells. Combination of ADJ with GLA, but not CpG, dampens T cell receptor (TCR) signaling, mitigates terminal differentiation of effectors, and enhances the development of CD4 and CD8 TRM cells that protect against H1N1 and H5N1 influenza viruses. Mechanistically, vaccine-elicited CD4 T cells play a vital role in optimal programming of CD8 TRM and viral control. Taken together, these findings provide further insights into vaccine-induced multifaceted mucosal T cell immunity with implications in the development of vaccines against respiratorypathogens, including influenza virus and SARS-CoV-2. |
| first_indexed | 2024-04-13T05:23:31Z |
| format | Article |
| id | doaj.art-88a86e830e69472c8aa0517dd36c33a6 |
| institution | Directory Open Access Journal |
| issn | 2666-3791 |
| language | English |
| last_indexed | 2024-04-13T05:23:31Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports Medicine |
| spelling | doaj.art-88a86e830e69472c8aa0517dd36c33a62022-12-22T03:00:40ZengElsevierCell Reports Medicine2666-37912020-09-0116100095Programming Multifaceted Pulmonary T Cell Immunity by Combination AdjuvantsChandranaik B. Marinaik0Brock Kingstad-Bakke1Woojong Lee2Masato Hatta3Michelle Sonsalla4Autumn Larsen5Brandon Neldner6David J. Gasper7Ross M. Kedl8Yoshihiro Kawaoka9M. Suresh10Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USADepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USADepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USADepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA; Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USADepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USADepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USADepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USADepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USADepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, USADepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA; Influenza Research Institute, University of Wisconsin-Madison, Madison, WI, USADepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA; Corresponding authorSummary: Induction of protective mucosal T cell memory remains a formidable challenge to vaccinologists. Using a combination adjuvant strategy that elicits potent CD8 and CD4 T cell responses, we define the tenets of vaccine-induced pulmonary T cell immunity. An acrylic-acid-based adjuvant (ADJ), in combination with Toll-like receptor (TLR) agonists glucopyranosyl lipid adjuvant (GLA) or CpG, promotes mucosal imprinting but engages distinct transcription programs to drive different degrees of terminal differentiation and disparate polarization of TH1/TC1/TH17/TC17 effector/memory T cells. Combination of ADJ with GLA, but not CpG, dampens T cell receptor (TCR) signaling, mitigates terminal differentiation of effectors, and enhances the development of CD4 and CD8 TRM cells that protect against H1N1 and H5N1 influenza viruses. Mechanistically, vaccine-elicited CD4 T cells play a vital role in optimal programming of CD8 TRM and viral control. Taken together, these findings provide further insights into vaccine-induced multifaceted mucosal T cell immunity with implications in the development of vaccines against respiratorypathogens, including influenza virus and SARS-CoV-2.http://www.sciencedirect.com/science/article/pii/S266637912030121XadjuvantsCD8CD4respiratory immunityinfluenza virusT1 and T17 programming |
| spellingShingle | Chandranaik B. Marinaik Brock Kingstad-Bakke Woojong Lee Masato Hatta Michelle Sonsalla Autumn Larsen Brandon Neldner David J. Gasper Ross M. Kedl Yoshihiro Kawaoka M. Suresh Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants Cell Reports Medicine adjuvants CD8 CD4 respiratory immunity influenza virus T1 and T17 programming |
| title | Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants |
| title_full | Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants |
| title_fullStr | Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants |
| title_full_unstemmed | Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants |
| title_short | Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants |
| title_sort | programming multifaceted pulmonary t cell immunity by combination adjuvants |
| topic | adjuvants CD8 CD4 respiratory immunity influenza virus T1 and T17 programming |
| url | http://www.sciencedirect.com/science/article/pii/S266637912030121X |
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