eIF2α confers cellular tolerance to S. aureus α-toxin

eIF2α confers cellular tolerance to S. aureus α-toxin

We report on the role of conserved stress-response pathways for cellular tolerance to a pore formingtoxin. First, we observed that small molecular weight inhibitors including of eIF2α-phosphatase, jun-N-terminal kinase (JNK), and PI3-kinase sensitized normal mouse embryonal fibroblasts (MEFs) to th...

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Bibliographic Details
Main Authors: Gisela evon Hoven, Claudia eNeukirch, Sabine eFüser, Maria eBidna Petrivna, Martina eMeyenburg, Amable J. Rivas, Alexey eRyazanov, Randal J. Kaufman, Raffi V. Aroian, Matthias eHusmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Immunology
Subjects:
JNK Mitogen-Activated Protein Kinases
MAPK
pore forming toxins
ADAM10
eIF2α
Cellular tolerance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00383/full

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http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00383/full

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