Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739

Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739

Adenosine monophosphate-activated protein kinase (AMPK) is a key energy sensor regulating the cell metabolism in response to energy supply and demand. The evolutionary adaptation of AMPK to different tissues is accomplished through the expression of distinct isoforms that can form up to 12 heterotri...

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Bibliographic Details
Main Authors: Elnaz Aledavood, Aria Gheeraert, Alessia Forte, Laurent Vuillon, Ivan Rivalta, F. Javier Luque, Carolina Estarellas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
AMPK
protein dynamic
protein activation mechanism
pan-activator
isoform selectivity
molecular dynamics simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.760026/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.760026/full

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