Single-cell transcriptomics highlights immunological dysregulations of monocytes in the pathobiology of COPD

Single-cell transcriptomics highlights immunological dysregulations of monocytes in the pathobiology of COPD

Abstract Background Chronic obstructive pulmonary disease (COPD) is a common respiratory disease, whose pathogenetic complexity was strongly associated with aging/smoking and poorly understood. Methods Here we performed single-cell RNA sequencing (scRNA-seq) analysis of 66,610 cells from COPD and ag...

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Bibliographic Details
Main Authors: Qiqing Huang, Yuanyuan Wang, Lili Zhang, Wei Qian, Shaoran Shen, Jingshen Wang, Shuangshuang Wu, Wei Xu, Bo Chen, Mingyan Lin, Jianqing Wu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Respiratory Research
Subjects:
COPD
Aging
Smoking
Single-cell RNA sequencing
Monocytes
Online Access:https://doi.org/10.1186/s12931-022-02293-2

Internet

https://doi.org/10.1186/s12931-022-02293-2

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