Massively parallel disruption of enhancers active in human neural stem cells

Summary: Changes in gene regulation have been linked to the expansion of the human cerebral cortex and to neurodevelopmental disorders, potentially by altering neural progenitor proliferation. However, the effects of genetic variation within regulatory elements on neural progenitors remain obscure....

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Bibliographic Details
Main Authors: Evan Geller, Mark A. Noble, Matheo Morales, Jake Gockley, Deena Emera, Severin Uebbing, Justin L. Cotney, James P. Noonan
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724000214