Inhibitory Effects of Simvastatin on IL-33-Induced MCP-1 via the Suppression of the JNK Pathway in Human Vascular Endothelial Cells

Inhibitory Effects of Simvastatin on IL-33-Induced MCP-1 via the Suppression of the JNK Pathway in Human Vascular Endothelial Cells

An alarmin, interleukin (IL)-33 is a danger signal that causes inflammation, inducing chemotactic proteins such as monocyte chemoattractant protein (MCP)-1 in various cells. As statins have pleiotropic actions including anti-inflammatory properties, we investigated the effects of simvastatin on IL-3...

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Bibliographic Details
Main Authors: Katsuyuki Umebashi, Masayoshi Yamamoto, Akinori Tokito, Ku Sudou, Yoko Takenoshita, Michihisa Jougasaki
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
interleukin-33
monocyte chemoattractant protein-1
cell migration
mitogen-activated protein kinase
cytokine
statins
Online Access:https://www.mdpi.com/1422-0067/24/16/13015

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https://www.mdpi.com/1422-0067/24/16/13015

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