Inhibitory Effects of Simvastatin on IL-33-Induced MCP-1 via the Suppression of the JNK Pathway in Human Vascular Endothelial Cells
An alarmin, interleukin (IL)-33 is a danger signal that causes inflammation, inducing chemotactic proteins such as monocyte chemoattractant protein (MCP)-1 in various cells. As statins have pleiotropic actions including anti-inflammatory properties, we investigated the effects of simvastatin on IL-3...
Main Authors: | Katsuyuki Umebashi, Masayoshi Yamamoto, Akinori Tokito, Ku Sudou, Yoko Takenoshita, Michihisa Jougasaki |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-08-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/24/16/13015 |
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